Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

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Abstract ACE2 overexpression in colorectal cancer patients might increase susceptibility to Outdoor Swivel Lounge Chair SARS-CoV-2 infection.We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis.In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor Supplements survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.